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Article

Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2005

Cipollone Francesco, Fazia Maria Luigia, Iezzi Annalisa, Cuccurullo Chiara, De Cesare Domenico, Ucchino Sante, Spigonardo Francesco, Marchetti Antonio, Buttitta Fiamma, Paloscia Leonardo, Mascellanti Marco, Cuccurullo Franco, Mezzetti Andrea

Abstract excerpt

OBJECTIVE: We recently demonstrated that inducible cyclooxygenase/PGE synthase-1 (COX-2/mPGES-1) are overexpressed in symptomatic plaques in association with PGE2-dependent metalloproteinase (matrix metalloproteinase [MMP]) biosynthesis and plaque rupture. However, it is not known which of the 4 PGE2 receptors (EP1-4) mediates macrophage metalloproteinase generation. The aim of this study was to characterize...

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Identifiers

PMID: 16020747
DOI: 10.1161/01.ATV.0000177814.41505.41

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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