Article
The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jul 2005
Cui Wilson W, Low Sean E, Hirata Hiromi, Saint-Amant Louis, Geisler Robert, Hume Richard I, Kuwada John Y
Abstract excerpt
shocked (sho) is a zebrafish mutation that causes motor deficits attributable to CNS defects during the first2dof development. Mutant embryos display reduced spontaneous coiling of the trunk, diminished escape responses when touched, and an absence of swimming. A missense mutation in the slc6a9 gene that encodes a glycine transporter (GlyT1) was identified as the cause of the sho phenotype. Antisense knock-down...
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