Article
Protease inhibitor (Pi) locus, fertility and twinning.
Human genetics - 1 May 1992
Boomsma D I, Frants R R, Bank R A, Martin N G
Abstract excerpt
In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an...
Topics
- Alleles
- Family Characteristics
- Female
- Fertility
- Gene Frequency
- Humans
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Pregnancy
- Pregnancy, Multiple