Article
Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.
Oncogene - 10 Nov 2005
Ahtiainen Petteri, Rulli Susana B, Shariatmadari Ramin, Pelliniemi Lauri J, Toppari Jorma, Poutanen Matti, Huhtaniemi Ilpo T
Abstract excerpt
We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age. In this study, the effects of persistently elevated hCG were followed in TG males between day 5 postpartum and adulthood. Leydig cell (LC) adenomas were found in prepubertal mice, most prominently at the age of 10 days, but not in adult...
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