Article
Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man.
Atherosclerosis - 1 Mar 2006
Laaksonen Reijo, Thelen Karin M, Päivä Hannu, Matinheikki Jussi, Vesalainen Risto, Janatuinen Tuula, Knuuti Juhani, Rontu Riikka, von Bergmann Klaus, Lütjohann Dieter, Lehtimäki Terho
Abstract excerpt
Sterol regulatory element binding proteins-1 and -2 (SREBPs) are transcription factors controlling lipid homeostasis in human cells. The G-allele carriers of the SREBF-1 gene C-G polymorphism in exon 18c and coding for glycine at the protein level (G952G) have shown to associate more frequently with obesity and type 2 diabetes than the C-allele carriers. However, the C-allele has suggested to be linked to...
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