Article
HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.
Virology - 1 Sept 2005
Louder Mark K, Sambor Anna, Chertova Elena, Hunte Tai, Barrett Sarah, Ojong Fallon, Sanders-Buell Eric, Zolla-Pazner Susan, McCutchan Francine E, Roser James D, Gabuzda Dana, Lifson Jeffrey D, Mascola John R
Abstract excerpt
Recombinant lentiviral vectors pseudotyped with heterologous HIV-1 envelope glycoproteins allow rapid and accurate measurement of antibody-mediated HIV-1 neutralization. However, the neutralization phenotypes of envelope pseudoviruses have not been directly compared to isogenic replication competent HIV-1. We produced pseudoviruses expressing three different HIV-1 envelope glycoproteins and subcloned the same...
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