Article
Angiotensin-converting enzyme (ACE) haplotypes and cyclosporine A (CsA) response: a model of the complex relationship between ACE quantitative trait locus and pathological phenotypes.
Human molecular genetics - 15 Aug 2005
Catarsi Paolo, Ravazzolo Roberto, Emma Francesco, Fruci Doriana, Finos Livio, Frau Andrea, Morreale Giacomo, Carrea Alba, Ghiggeri Gian Marco
Abstract excerpt
It is highly controversial to define the role of angiotensin-converting enzyme (ACE) polymorphisms in essential hypertension. We studied a group of patients in whom hypertension was the major side effect of treatment by cyclosporine A (CsA). This study group comprised 227 Italian patients with nephrotic syndrome, 103 of which were treated with CsA and had different outcome. Forty-nine patients developed serious...
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