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Article

The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer

1 Jan 2005

Abstract excerpt

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DNA-PK activity was...

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PMID: 16000400
DOI: 10.1093/carcin/bgi175

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