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Article

Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

1 Oct 2003

Abstract excerpt

DNA-PK is a nuclear protein with serine/threonine kinase activity and forms a complex consisting of the DNA-PKcs and a heterodimer of Ku70 and Ku80 proteins. Recent laboratory experiments have demonstrated that the DNA-PK complex formation is one of the major pathways by which mammalian cells respond to DNA double-strand breaks induced by ionizing radiation. In this study, we evaluated the relationship between...

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PMID: 14556663
DOI: 10.1111/j.1349-7006.2003.tb01372.x

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