Prediction of resistance to erythromycin in the genus Rickettsia by mutations in L22 ribosomal protein.

Abstract excerpt

OBJECTIVES: Typhus group (TG) rickettsiae are naturally susceptible to erythromycin whereas spotted fever group (SFG) rickettsioses are not. The aim of this study was to compare in silico genetic determinants known to be associated with resistance to macrolide compounds. METHODS AND RESULTS: Available sequences of the 23S RNA gene, and L4 and L22 ribosomal proteins of rickettsial strains were aligned and compared...

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