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Article

The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo.

Cancer research - 1 Jul 2005

Osthus Rebecca C, Karim Baktiar, Prescott Julia E, Smith B Douglas, McDevitt Michael, Huso David L, Dang Chi V

Abstract excerpt

MYC is frequently overexpressed in human cancers, but the downstream events contributing to tumorigenesis remain incompletely understood. MYC encodes an oncogenic transcription factor, of which target genes presumably contribute to cellular transformation. Although Myc regulates about 15% of genes and combinations of target genes are likely required for tumorigenesis, we studied in depth the expression of the Myc...

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Source

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Identifiers

PMID: 15994934
DOI: 10.1158/0008-5472.CAN-05-0536
PMCID: PMC1224734

Genes

CDCA7
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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