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Article

Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans.

Journal of medical genetics - 1 Jul 2005

Mogil J S, Ritchie J, Smith S B, Strasburg K, Kaplan L, Wallace M R, Romberg R R, Bijl H, Sarton E Y, Fillingim R B, Dahan A

Abstract excerpt

BACKGROUND: A recent genetic study in mice and humans revealed the modulatory effect of MC1R (melanocortin-1 receptor) gene variants on kappa-opioid receptor mediated analgesia. It is unclear whether this gene affects basal pain sensitivity or the efficacy of analgesics acting at the more clinically relevant mu-opioid receptor. OBJECTIVE: To characterise sensitivity to pain and mu-opioid analgesia in mice and...

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Identifiers

PMID: 15994880
DOI: 10.1136/jmg.2004.027698
PMCID: PMC1736101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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