Article
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003
Mogil Jeffrey S, Wilson Sonya G, Chesler Elissa J, Rankin Andrew L, Nemmani Kumar V S, Lariviere William R, Groce M Kristina, Wallace Margaret R, Kaplan Lee, Staud Roland, Ness Timothy J, Glover Toni L, Stankova Magda, Mayorov Alexander, Hruby Victor J, Grisel Judith E, Fillingim Roger B
Abstract excerpt
Sex specificity of neural mechanisms modulating nociceptive information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant to analgesia from kappa-opioid receptor agonists, a drug class reported to be clinically effective only in women. Via quantitative trait locus mapping followed by a candidate gene strategy using both mutant mice and pharmacological tools, we now...
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