[Genetic polymorphisms and human sensitivity to pain and opioids].

Abstract excerpt

It has been known widely that sensitivity to pain and opioid analgesics varies widely among individual subjects. Because of this variability, a dose of an opioid analgesic that can produce satisfactory pain relief without adverse effects in some patients might cause underdosing or overdosing in other patients, which is often problematic in the clinic. Individual differences can be attributed to both genetic and...

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