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Article

Glutathione is required for growth and prespore cell differentiation in Dictyostelium.

Developmental biology - 15 Aug 2005

Kim Beom-Jun, Choi Chang-Hoon, Lee Chang-Hun, Jeong Sun-Young, Kim Ji-Sun, Kim Bo-Yeon, Yim Hyung-Soon, Kang Sa-Ouk

Abstract excerpt

Glutathione (GSH) is the most abundant non-protein thiol in eukaryotic cells and acts as reducing equivalent in many cellular processes. We investigated the role of glutathione in Dictyostelium development by disruption of gamma-glutamylcysteine synthetase (GCS), an essential enzyme in glutathione biosynthesis. GCS-null strain showed glutathione auxotrophy and could not grow in medium containing other thiol...

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PMID: 15993406
DOI: 10.1016/j.ydbio.2005.05.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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