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Article

Beware of multiple comparisons: a study of symptoms associated with mutations of the HFE hemochromatosis gene.

Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2005

Waalen Jill, Beutler Ernest

Abstract excerpt

BACKGROUND: Studies involving a large number of comparisons have a high likelihood of finding statistically significant associations by chance alone (Type 1 error). Genetic association studies are particularly prone to this pitfall. We tested the effect of multiple comparisons in a study of symptoms among subjects genotyped for mutations of the HFE hemochromatosis gene. METHODS: Two randomly selected groups were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15993396
DOI: 10.1016/j.cccn.2005.05.017

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beware of multiple comparisons: a study of symptoms associated with mutations of the HFE hemochromatosis gene.PMID 15993396Read ↗

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