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Article

Prevalence of hemochromatosis-related symptoms among individuals with mutations in the HFE gene.

Mayo Clinic proceedings - 1 Jun 2002

Waalen Jill, Felitti Vincent, Gelbart Terri, Ho Ngoc J, Beutler Ernest

Abstract excerpt

OBJECTIVE: To determine the prevalence of hemochromatosis-related symptoms in homozygotes for the HFE mutation C282Y compared with controls without HFE mutations identified through a large screening program of subjects attending a health appraisal center. SUBJECTS AND METHODS: Presence of symptoms commonly associated with clinical hemochromatosis was ascertained by self-report on a written questionnaire among...

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Identifiers

PMID: 12059121
DOI: 10.4065/77.6.522

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of hemochromatosis-related symptoms among individuals with mutations in the HFE gene.PMID 12059121Read ↗

Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening.Semantic proximity Read ↗

Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.Semantic proximity Read ↗

Beware of multiple comparisons: a study of symptoms associated with mutations of the HFE hemochromatosis gene.Semantic proximity Read ↗

HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis.Semantic proximity Read ↗

Iron-Overload–Related Disease in<i>HFE</i>Hereditary HemochromatosisSemantic proximity Read ↗

The significance of haemochromatosis gene mutations in the general population: implications for screening.Semantic proximity Read ↗

Arthritis in hemochromatosis or iron storage disease.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity # †Semantic proximity Read ↗

HFE mutations in the elderly.Semantic proximity Read ↗

Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States.Semantic proximity Read ↗

HFE gene mutation (C282Y) and phenotypic expression among a hospitalised population in a high prevalence area of haemochromatosis.Semantic proximity Read ↗

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