Article
Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects.
Circulation. Cardiovascular genetics - 1 Oct 2008
van der A Daphne L, Rovers Maroeska M, Grobbee Diederick E, Marx Joannes J M, Waalen Jill, Ellervik Christina, Nordestgaard Børge G, Olynyk John K, Mills Peter R, Shepherd James, Grandchamp Bernard, Boer Jolanda M A, Caruso Calogero, Arca Marcello, Meyer Beat J, van der Schouw Yvonne T
Abstract excerpt
BACKGROUND: Whether mutations in the hemochromatosis (HFE) gene increase cardiovascular disease risk is still undetermined. The main reason is the low frequency of the mutations, in particular of the compound C282Y/H63D genotype. We combined the data of 11 observational studies for an individual patient data meta-analysis. METHODS AND RESULTS: Individual patient data were obtained from published as well as...
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