Article
Expression of Rac3 in human brain tumors.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Jun 2005
Hwang Shiuh-Lin, Chang Jing-Hon, Cheng Tai-Shan, Sy Wei-Di, Lieu Ann-Shung, Lin Chih-Lung, Lee Kung-Shing, Howng Shen-Long, Hong Yi-Ren
Abstract excerpt
Rac3 may play an important role in tumor growth but little is known about its expression and mutation in human tumor tissues. We examined the expression of Rac3 using RT-PCR and mutation of the Rac3 gene by DNA sequencing. Overexpression of the Rac3 gene occurred in 19% (5/26) of brain tumors; 3 of 9 (33%) meningiomas, 1 of 11 (9%) astrocytomas and 1 of 6 (17%) pituitary adenomas. Two of the 3 meningiomas with...
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