Article
Rac2 expression and mutation in human brain tumors.
Acta neurochirurgica - 1 May 2005
Hwang S-L, Lieu A-S, Chang J-H, Cheng T-S, Cheng C-Y, Lee K-S, Lin C-L, Howng S-L, Hong Y-R
Abstract excerpt
BACKGROUND: Rac1 and Rac2 are interchangeable in NADPH oxidase activation. Rac1 plays an important role in regulating nuclear signalling and in the activation of transcriptional factors that regulate gene expression and cell growth. Our previous study observed mutation in effector region of Rac1 gene in brain tumors. Little is known about the expression and mutation of Rac2 in human brain tumors. METHOD: We...
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