Article
Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients.
Diabetes care - 1 Jul 2005
Baum Larry, Ng Maggie C Y, So Wing-Yee, Lam Vincent K L, Wang Ying, Poon Emily, Tomlinson Brian, Cheng Suzanne, Lindpaintner Klaus, Chan Juliana C N
Abstract excerpt
OBJECTIVE: Triglyceride-rich lipoprotein particles may promote the progression of diabetic nephropathy. Patients with diabetic nephropathy have increased plasma triglycerides and reduced activity of hepatic lipase (HL), which hydrolyzes triglycerides. We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3...
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