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Article

Reassessing the role of progesterone in fertilization—compartmentalized calcium signalling in human spermatozoa?

24 Jun 2005

Abstract excerpt

Progesterone is present at micromolar concentrations in the vicinity of the oocyte. Human spermatozoa generate a biphasic rise in intracellular calcium concentration ([Ca(2+)](i)) and undergo the acrosome reaction upon progesterone stimulation, suggesting that the hormone acts as a secondary inducer or 'primer' of the acrosome reaction in association with the zona pellucida. However, the sensitivity of human...

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PMID: 15980011
DOI: 10.1093/humrep/dei158

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