Article
Characterization of murine cell lines from diethylstilbestrol-induced uterine endometrial adenocarcinomas.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 May 1992
Hébert C D, Endo S, Korach K S, Boyd J, Barrett J C, McLachlan J A, Newbold R R
Abstract excerpt
Neonatal treatment with estrogens is associated with development of uterine adenocarcinomas in CD-1 mice. Treatment with the synthetic estrogen diethylstilbestrol (DES) on Days 1 to 5 after birth results in 90% incidence of these hormone-dependent lesions in 18-mo.-old mice. Three cell lines were established from these DES-associated tumors. Each of these cell lines exhibited morphologic and ultrastructural...
Topics
- Adenocarcinoma
- Animals
- Blotting, Southern
- Cell Nucleolus
- Cell Nucleus
- Chromatin
- Cytoplasm
- DNA, Neoplasm
- Diethylstilbestrol
- Female
- Genes, Tumor Suppressor