Article
Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila melanogaster: II. Adh allozymes in an isogenic background.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1994
Eisses K T
Abstract excerpt
Pyrazole and 4-methylpyrazole (4-MP) are in vivo and in vitro inhibitors of alcohol dehydrogenase activity in mammals. The fruitfly Drosophila melanogaster has been used to demonstrate the influence of genetic variation in alcohol dehydrogenase alleles on the results of larval treatment with pyrazole and 4-MP. Genetic polymorphism of organisms involved in experiments with teratogenic and toxic agents is not often...
Topics
- Abnormalities, Drug-Induced
- Alcohol Dehydrogenase
- Animals
- Chromosome Mapping
- Drosophila melanogaster
- Female
- Fomepizole
- Genetic Variation
- Isoenzymes
- Male
- Pyrazoles