Article
Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000
Kaur Ravinder, Nagpal Jatin K, Das Bibhu R
Abstract excerpt
Insulin and insulin-like growth factors (IGFs) are major determinants of proliferation and apoptosis, thereby playing a significant role in carcinogenesis. Epidemiological evidence associates high levels of INS and IGFs with an increased risk of cancer. Polymorphism of the genes involved in insulin-signaling pathways has been associated with a variable risk for neoplasms in different ethnic and environmental...
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