Article
Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000
Kaur Ravinder, Nagpal Jatin K, Das Bibhu R
Abstract excerpt
Insulin and insulin-like growth factors (IGFs) are major determinants of proliferation and apoptosis, thereby playing a significant role in carcinogenesis. Epidemiological evidence associates high levels of INS and IGFs with an increased risk of cancer. Polymorphism of the genes involved in insulin-signaling pathways has been associated with a variable risk for neoplasms in different ethnic and environmental...
Topics
- Carcinoma, Squamous Cell
- Case-Control Studies
- Ethnicity
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypoglycemic Agents
- India
- Insulin
- Insulin-Like Growth Factor II
- Mouth Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Tobacco, Smokeless