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Article

Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase.

The Journal of biological chemistry - 26 Aug 2005

Huang Yu Chu, Colman Roberta F

Abstract excerpt

The structure of crystalline porcine mitochondrial NADP-dependent isocitrate dehydrogenase (IDH) has been determined in complex with Mn2+-isocitrate. Based on structural alignment between this porcine enzyme and seven determined crystal structures of complexes of NADP with bacterial IDHs, Arg83, Thr311, and Asn328 were chosen as targets for site-directed mutagenesis of porcine IDH. The circular dichroism spectra...

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Identifiers

PMID: 15975917
DOI: 10.1074/jbc.M505828200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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