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Article

Alteration of the Copy Number of Mitochondrial DNA in Leukocytes of Patients with Hyperlipidemia

1 May 2005

Abstract excerpt

Lipid metabolism in leukocytes may be disturbed by mitochondrial dysfunction caused by depletion of mitochondrial DNA (mtDNA) in response to an increase of oxidative stress in blood circulation. It is possible that alteration in mtDNA copy number of the leukocyte is involved in the impairment of the scavenging of oxidatively modified plasma proteins such as oxidized low-density lipoprotein (oxLDL). To test this...

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Share to Atherosclerosis and Cardiovascular Diseases
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PMID: 15965047
DOI: 10.1196/annals.1338.008

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