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Article

Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases.

Journal of the neurological sciences - 15 Jan 2008

Liu Chin-San, Cheng Wen-Ling, Kuo Shou-Jen, Li Jie-Yuan, Soong Bing-Wen, Wei Yau-Huei

Abstract excerpt

Polyglutamine (poly-Q) diseases are late-onset neurodegenerative disorders arising from the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract of glutamine residues. This kind of mutant proteins may be aggregated and accumulated, and thereby enhance cellular oxidative stress. In one of our previous studies (Free Radic. Res. 2003;37:1307-17), we found that alteration in the...

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Identifiers

PMID: 17720200
DOI: 10.1016/j.jns.2007.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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