Transcript Profiling of Immediate Early Genes Reveals a Unique Role for Activating Transcription Factor 3 in Mediating Activation of the Glycoprotein Hormone α-Subunit Promoter by Gonadotropin-Releasing Hormone

Abstract excerpt

Recent studies profiling immediate early gene responses to GnRH in the LbetaT2 gonadotrope cell model revealed increased expression of numerous genes including activating transcription factor (ATF) 3. The present studies demonstrate similar results with GnRH administration in vivo in ovariectomized mice. In this model, ATF3 mRNA was markedly up-regulated at 20, 40, and 60 min after in vivo administration of a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Ovarian function and disorders