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Article

Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol.

Carcinogenesis - 1 Jul 2003

Mammen Jennifer S, Pittman Gary S, Li Ying, Abou-Zahr Fadi, Bejjani Bassem A, Bell Douglas A, Strickland Paul T, Sutter Thomas R

Abstract excerpt

Genetic differences that underlie inter-individual variation in the metabolism of common carcinogens are important potential sources of cancer susceptibility. Cytochrome P450 1B1 (CYP1B1), a central enzyme in the activation of the ubiquitous environmental carcinogen benzo[a]pyrene (B[a]P), has several genetic variants. This study investigated six rare mutations and four common polymorphisms for their effects on...

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Identifiers

PMID: 12807732
DOI: 10.1093/carcin/bgg088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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