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Iron-Sulfur Cluster Biogenesis Chaperones: Evidence for Emergence of Mutational Robustness of a Highly Specific Protein-Protein Interaction.

Molecular biology and evolution - 1 Mar 2016

Delewski Wojciech, Paterkiewicz Bogumiła, Manicki Mateusz, Schilke Brenda, Tomiczek Bartłomiej, Ciesielski Szymon J, Nierzwicki Lukasz, Czub Jacek, Dutkiewicz Rafal, Craig Elizabeth A, Marszalek Jaroslaw

Abstract excerpt

Biogenesis of iron-sulfur clusters (FeS) is a highly conserved process involving Hsp70 and J-protein chaperones. However, Hsp70 specialization differs among species. In most eukaryotes, including Schizosaccharomyces pombe, FeS biogenesis involves interaction between the J-protein Jac1 and the multifunctional Hsp70 Ssc1. But, in Saccharomyces cerevisiae and closely related species, Jac1 interacts with the...

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PMID: 26545917
DOI: 10.1093/molbev/msv254
PMCID: PMC5009999

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