Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.

British journal of cancer - 25 Jul 2005

Wey J S, Gray M J, Fan F, Belcheva A, McCarty M F, Stoeltzing O, Somcio R, Liu W, Evans D B, Klagsbrun M, Gallick G E, Ellis L M

Abstract excerpt

Neuropilin-1 (NRP-1) is a novel co-receptor for vascular endothelial growth factor (VEGF). Neuropilin-1 is expressed in pancreatic cancer, but not in nonmalignant pancreatic tissue. We hypothesised that NRP-1 expression by pancreatic cancer cells contributes to the malignant phenotype. To determine the role of NRP-1 in pancreatic cancer, NRP-1 was stably transfected into the human pancreatic cancer cell line FG....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Alkylating
Share to Deoxycytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Gemcitabine

Share to Mitogen-Activated Protein Kinases

Share to Neuropilin-1

Share to Pancreatic Neoplasms

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 15956974
DOI: 10.1038/sj.bjc.6602663
PMCID: PMC2361553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.PMID 15956974Read ↗

Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 CoreceptorsSemantic proximity Read ↗

Jack of many trades: Multifaceted role of neuropilins in pancreatic cancerSemantic proximity Read ↗

The role of neuropilins in cancerSemantic proximity Read ↗

Neuropilins Controlling Cancer Therapy ResponsivenessSemantic proximity Read ↗

Neuropilins: expression and roles in the epitheliumSemantic proximity Read ↗

Neuropilins in Tumor BiologySemantic proximity Read ↗

Neuropilins in neoplasms: Expression, regulation, and functionSemantic proximity Read ↗

PLK1 inhibition enhances gemcitabine-induced apoptosis through PLK1-dependent ERK1/2-BIM and AKT1/NOXA signals in pancreatic cancer cellsSemantic proximity Read ↗

Roles of Neuropilins in Neuronal Development, Angiogenesis, and CancersSemantic proximity Read ↗

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumorsSemantic proximity Read ↗

Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancerSemantic proximity Read ↗

Neuropilins: structure, function and role in diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.