Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors.

Blood - 1 Oct 2005

Poggi Alessandro, Negrini Simone, Zocchi Maria Raffaella, Massaro Anna-Maria, Garbarino Lucia, Lastraioli Sonia, Gargiulo Lucia, Luzzatto Lucio, Notaro Rosario

Abstract excerpt

Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a large clonal population of blood cells deriving from hematopoietic stem cells (HSCs) deficient in glycosylphosphatidylinositol (GPI)-anchored surface molecules. A current model postulates that PNH arises through negative selection against normal HSCs exerted by autoreactive T cells, whereas PNH HSCs escape damage. We have investigated the inhibitory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD3 Complex
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylphosphatidylinositols

Share to Hematopoietic Stem Cells

Share to Hemoglobinuria, Paroxysmal

Share to Interferon-gamma

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Source

Identifiers

PMID: 15956278
DOI: 10.1182/blood-2004-11-4315

Genes

GPI
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors.PMID 15956278Read ↗

Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients.Semantic proximity Read ↗

T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway.Semantic proximity Read ↗

Immune pressure on hematopoietic stem cells can drastically expand glycosylphosphatidylinositol-deficient clones in paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammationSemantic proximity Read ↗

Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Immune pathogenesis of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH.Semantic proximity Read ↗

Molecular genetics of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

[Paroxysmal nocturnal hemoglobinuria].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.