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Monozygotic Twins Discordant for Huntington Disease After 7 Years

1 Jun 2005

Abstract excerpt

BACKGROUND: Huntington disease (HD) has only rarely been identified in identical twins. All described twins have had disease onset within 1 year of each other, suggesting that disease onset is determined solely by genetic influences. OBJECTIVE: To describe a unique set of monozygotic twins in whom clinical HD onset is at least 7 years apart. DESIGN: A 71-year-old woman was diagnosed as having HD based on medical...

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PMID: 15956172
DOI: 10.1001/archneur.62.6.995

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