Article
Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates.
The Journal of antimicrobial chemotherapy - 1 Aug 2005
Gillespie Stephen H, Basu Shreya, Dickens Anne L, O'Sullivan Denise M, McHugh Timothy D
Abstract excerpt
OBJECTIVES: Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and staphylococci. The purpose of this study is to extend this observation to mycobacteria and to quantify mutation rates. METHODS: The mutation rate in Mycobacterium fortuitum...
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