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Article

Regulation of HPV-16 infection by ubiquitination of the L1 major capsid protein.

Journal of virology - 19 May 2026

Trejo-Cerro Oscar, Bergant Marušič Martina, Wlodarczyk Patryk, Repnik Urška, Lovšin Nika, Myers Michael P, Garcea Robert L, Banks Lawrence, Broniarczyk Justyna

Abstract excerpt

The L1 major capsid protein of the papillomavirus is critical for both viral assembly and entry into host cells, but the impact of its post-translational modifications on the HPV life cycle remains poorly understood. In this study, we show, for the first time, that HPV16 L1 is ubiquitinated at several conserved lysine residues (K20, K64, K152, K217, K437, K452, and K454) identified by mass spectrometry. Mutations...

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Share to Capsid Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Viral

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Source

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Identifiers

PMID: 41973535
DOI: 10.1128/jvi.00285-26
PMCID: PMC13185570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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