Article
Increased risk of cervical cancer associated with cyclin D1 gene A870G polymorphism.
Cancer genetics and cytogenetics - 1 Jul 2005
Catarino Raquel, Matos Ana, Pinto Daniela, Pereira Deolinda, Craveiro Rogéria, Vasconcelos André, Lopes Carlos, Medeiros Rui
Abstract excerpt
Human papillomavirus (HPV) plays a major role in the etiology of cervical cancer. However, a complex correlation between viral and cellular genes is necessary for cell cycle control deregulation in the progression to invasive cervical cancer (ICC). Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. The CCND1 gene is located at 11q13 and is often altered in human cancers. We...
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