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Mating worms and the cystic kidney: Caenorhabditis elegans as a model for renal disease.

Pediatric nephrology (Berlin, Germany) - 1 Nov 2005

Lipton Jonathan

Abstract excerpt

Polycystic kidney disease (PKD) is caused by a group of variably inherited human disorders that are major causes of end-stage renal disease in both children and adults. The genetic culprits responsible for autosomal-dominant PKD (ADPKD), the polycystins, have been identified, yet still little is known about the molecular mechanisms that result in the disease phenotype. Polycystin homologs have been isolated in...

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PMID: 15947985
DOI: 10.1007/s00467-005-1958-x

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