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Article

Spatial and temporal localization during embryonic and fetal human development of the transcription factor <i>SIM2</i> in brain regions altered in Down syndrome

8 Jun 2005

Abstract excerpt

Human SIM2 is the ortholog of Drosophila single-minded (sim), a master regulator of neurogenesis and transcriptional factor controlling midline cell fate determination. We previously localized SIM2 in a chromosome 21 critical region for Down syndrome (DS). Here, we studied SIM2 gene using a new approach to provide insights in understanding of its potential role in human development. For the first time, we showed...

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PMID: 15946822
DOI: 10.1016/j.ijdevneu.2005.05.004

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