Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells.

doi:10.1111/j.1365-2567.2005.02163.x

Article

Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells.

Immunology - 1 Jul 2005

Mahnke Yolanda D, Schwendemann Jochen, Beckhove Philipp, Schirrmacher Volker

Abstract excerpt

LacZ (Gal)-reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal-expressing syngeneic tumour cells (ESbL-Gal) in order to study tumour-protective T-cell memory. This transfer prevented tumour outgrowth in recipients and resulted in the persistence of a high frequency of Gal-specific CD8(+) T cells in the bone marrow and spleen. In contrast, such Ag-specific memory CD8(+) T cells were...

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Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells.

Abstract excerpt

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