Article
Tumor-immune memory T cells from the bone marrow exert GvL without GvH reactivity in advanced metastasized cancer.
International journal of oncology - 1 Oct 2005
Schirrmacher Volker, Beckhove Philipp, Choi Carmen, Griesbach Andreas, Mahnke Yolanda
Abstract excerpt
The bone marrow has been shown to represent a unique microenvironment where T cell immune responses against tumor associated antigens can be initiated and tumor-immune memory T cells are enriched. In the present study the graft versus leukemia (GvL) reactivity of bone marrow derived tumor-immune memory T cells was analyzed in an allogeneic minor histocompatibility different murine GvL tumor model with late stage...
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