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Article

Polymorphism of the MUC1 mucin gene is associated with susceptibility to lung adenocarcinoma and poor prognosis.

Oncology reports - 1 Jul 2005

Mitsuta Kazuhiro, Yokoyama Akihito, Kondo Keiichi, Nakajima Masamitsu, Arita Ken-ichi, Kohno Nobuoki

Abstract excerpt

MUC1 is a highly glycosylated glycoprotein that is often overexpressed in adenocarcinomas. MUC1 has molecular diversity because of a variable number of tandem repeats (from 25-125 repeats) in the extracellular domain of its core protein. MUC1 plays an important role in facilitating invasion and metastasis of malignant cells, and it also inhibits anti-cancer immune activity against malignant cells. We hypothesize...

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Adenocarcinoma
Aged, 80 and over
Carcinoma, Squamous Cell
Lung Neoplasms
Mucin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Survival Analysis

Source

Identifiers

PMID: 15944787

Genes

MUC1

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