Article
Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
BMC genomics - 10 Dec 2004
Taudien Stefan, Galgoczy Petra, Huse Klaus, Reichwald Kathrin, Schilhabel Markus, Szafranski Karol, Shimizu Atsushi, Asakawa Shuichi, Frankish Adam, Loncarevic Ivan F, Shimizu Nobuyoshi, Siddiqui Roman, Platzer Matthias
Abstract excerpt
BACKGROUND: Defensins are important components of innate immunity to combat bacterial and viral infections, and can even elicit antitumor responses. Clusters of defensin (DEF) genes are located in a 2 Mb range of the human chromosome 8p23.1. This DEF locus, however, represents one of the regions in the euchromatic part of the final human genome sequence which contains segmental duplications, and recalcitrant gaps...
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