Article
1H-NMR metabolic markers of malignancy correlate with spontaneous metastases in a murine mammary tumor model.
International journal of oncology - 1 Jul 2005
Whitehead Tracy L, Monzavi-Karbassi Behjatolah, Jousheghany Fariba, Artaud Cecile, Elbein Alan, Kieber-Emmons Thomas
Abstract excerpt
End-products of glycolysis as well as phospholipid precursors and catabolites have been suggested as metabolic indicators of tumor progression. To test the hypothesis that increased levels of such indicators can distinguish metastatic phenotypes, we determined a limited cellular 1H-NMR metabolic profile of subpopulations of murine mammary 4T1 cells that differ in their metastatic potential. Subpopulations with...
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