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Article

Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.

DNA and cell biology - 1 Jun 2005

Adachi Noritaka, Iiizumi Susumu, Koyama Hideki

Abstract excerpt

DNA topoisomerase II (Top2) inhibitors are useful as anticancer agents, mostly by virtue of their ability to induce DNA double-strand breaks (DSBs). These DSBs are repaired almost exclusively by Rad52-dependent homologous recombination (HR) in yeast. However, we have recently shown that in vertebrate cells such lesions are primarily repaired by nonhomologous end-joining, but not HR. This finding, taken together...

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Source

Identifiers

PMID: 15941391
DOI: 10.1089/dna.2005.24.388

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 9 closest

Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.PMID 15941391Read ↗

Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.Semantic proximity Read ↗

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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1Semantic proximity Read ↗

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A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.Semantic proximity Read ↗

Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.Semantic proximity Read ↗

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