Article
Lineage-specific methylation of the c-fms gene in blood cells and macrophages.
Leukemia - 1 May 1992
Felgner J, Kreipe H, Heidorn K, Jaquet K, Heuss R, Zschunke F, Radzun H J, Parwaresch M R
Abstract excerpt
DNA methylation belongs to the multilevel genetic control system regulating differentiation processes and gene expression. The extent to which DNA methylation contributes to the differentiation of hematopoietic cells is elusive. In the present study we investigated the methylation state of the c-fms/M-CSF receptor gene in normal human blood cells and tissue macrophages. The methylation pattern of the c-fms gene...
Topics
- Alleles
- Blood Cells
- DNA
- Exons
- Gene Expression Regulation
- Genes, fms
- Hematopoietic Stem Cells
- Humans
- Macrophages
- Macrophages, Alveolar
- Methylation
- Receptors, Colony-Stimulating Factor