Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.

doi:10.1002/ajmg.a.30779

Article

Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.

American journal of medical genetics. Part A - 1 Jul 2005

Itoyama Satoru, Keicho Naoto, Hijikata Minako, Quy Tran, Phi Nguyen Chi, Long Hoang Thuy, Ha Le Dang, Ban Vo Van, Matsushita Ikumi, Yanai Hideki, Kirikae Fumiko, Kirikae Teruo, Kuratsuji Tadatoshi, Sasazuki Takehiko

Abstract excerpt

We analyzed genetic variations of angiotensin-converting enzyme 2 (ACE2), considering that it might influence patients' susceptibility to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) or development of SARS as a functional receptor. By cloning of the full-length cDNA of the ACE2 gene in the lung, where replication occurs on SARS-CoV, it was shown that there are different splicing sites. All...

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Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.

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