Article
CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia.
American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2005
Zabner Joseph, Scheetz Todd E, Almabrazi Hakeem G, Casavant Thomas L, Huang Jian, Keshavjee Shaf, McCray Paul B
Abstract excerpt
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel regulated by phosphorylation. Most of the disease-associated morbidity is the consequence of chronic lung infection with progressive tissue destruction. As an approach to investigate the cellular effects of CFTR mutations, we used large-scale microarray hybridization to...
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