Article
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Trkola Alexandra, Kuhmann Shawn E, Strizki Julie M, Maxwell Elizabeth, Ketas Tom, Morgan Tom, Pugach Pavel, Xu Serena, Wojcik Lisa, Tagat Jayaram, Palani Anandan, Shapiro Sherry, Clader John W, McCombie Stuart, Reyes Gregory R, Baroudy Bahige M, Moore John P
Abstract excerpt
To study HIV-1 escape from a coreceptor antagonist, the R5 primary isolate CC1/85 was passaged in peripheral blood mononuclear cells with increasing concentrations of the CCR5-specific small molecule inhibitor, AD101. By 19 passages, an escape mutant emerged with a >20,000-fold resistance to AD101. This virus was cross-resistant to a related inhibitor, SCH-C, and partially resistant to RANTES but still sensitive...
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