Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.

doi:10.1016/j.ygcen.2005.02.009

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Article

Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.

General and comparative endocrinology - 1 Jul 2005

Tu Meng-Ping, Yin Chih-Ming, Tatar Marc

Abstract excerpt

Juvenile hormone (JH) is a key endocrine regulator of insect metamorphosis, reproduction, and aging. The synthesis of JH is regulated by neuropeptides and biogenic amines, but the molecular and cellular basis of this control remains largely unknown. Genetic analysis of JH synthesis in Drosophila melanogaster mutant for insulin signaling may provide new and powerful insights. Mutants of the insulin receptor (InR)...

Topics

Animals
Brain
Corpora Allata
Drosophila Proteins
Drosophila melanogaster
Female
Fluorescent Antibody Technique
Insect Hormones
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides and Proteins
Juvenile Hormones
Mutation
Neuropeptides
Receptor, Insulin
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 15935161
DOI: 10.1016/j.ygcen.2005.02.009

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