Article
Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.
General and comparative endocrinology - 1 Jul 2005
Tu Meng-Ping, Yin Chih-Ming, Tatar Marc
Abstract excerpt
Juvenile hormone (JH) is a key endocrine regulator of insect metamorphosis, reproduction, and aging. The synthesis of JH is regulated by neuropeptides and biogenic amines, but the molecular and cellular basis of this control remains largely unknown. Genetic analysis of JH synthesis in Drosophila melanogaster mutant for insulin signaling may provide new and powerful insights. Mutants of the insulin receptor (InR)...
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